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Recipients will comply with requirements of the Federal regulations at 45 CFR Part 46 , which requires recipients to comply with the applicable provisions/law for protection of human subjects for purposes of research. Recipients must also comply with the requirements of DHS Management Directive 026-04, Protection of Human Subjects, prior to implementing any work with human subjects . For purposes of 45 CFR Part 46 , research means a systematic investigation, including research, development, testing, and evaluation, designed to develop or contribute to general knowledge . Activities that meet this definition constitutes research for purposes of this policy, whether or not they are conducted or supported under a program that is considered research for other purposes . The regulations specify additional protections for research involving human fetuses, pregnant women, and neonates (Subpart B) : prisoners (Subpart C) ; and children (Subpart D) . The use of autopsy materials is governed by applicable state and local law and is not directly regulated by 45 CFR Part 46 . Article XXIV— National Flood Insurance Act of 1968 Recipients will comply with the requirements of Section 1306(c) of the National Flood Insurance Act, as amended, which provided for benefit payments under the Standard Flood Insurance Policy for demolition or relocation of a structure insured under the Act that is located along the shore of a lake or other body of water and that is certified by an appropriate State or local land use authority to be subject to imminent collapse or subsidence as a result of erosion or undermining caused by waved exceeding anticipated cyclical levels . These regulations are codified at 44 CFR Part 663 . Article XXV— Flood Disaster Protection Act of 1973 Recipients will comply with the requirements of the Flood Disaster Act of 1973 , as amended (42 U . S . C . 4001 et seq. ), which provides that no Federal financial assistance to acquire , modernize, or construct property may be provided in identified flood-prone communities in the United Stated, unless the community participates in the National Flood Insurance Program and flood insurance is purchases within one year of the identification. The flood insurance purchase requirement applies to both public and private applicants for DHS support. Lists of flood prone areas that are eligible for flood insurance are published in the Federal Registry by FEMA . Article XXVI — Coastal Wetlands Planning, Protection, and Restoration Act of 1990 Recipients will comply with the requirements of Executive Order 1190 , which provides that federally funded construction and improvements minimize the destruction, loss or degradation of wetlands . The Executive Order provides that, in furtherance of Section 101 (b) (3 ) of NEPA (42 U. S . C . 4331 (b) (3 )), Federal agencies , to the extent permitted by law, must avoid undertaking or assisting with new construction located in wetlands unless the head of the agency finds that there is no practicable alternative to such construction, and that the proposed action includes all practicable measures to minimize harm to wetlands that may result from such use . In making this finding, the head of the agency may take into account economic, environmental, and other Page 37 of 48